Reduced anterior cingulate cortex volume induced by chronic stress correlates with increased behavioral emotionality and decreased synaptic puncta density.

Neuropharmacology, April 2021

Authors: Keith A. Misquitta, Amy Miles, Thomas D. Prevot, Jaime K. Knoch, Corey Fee, Dwight F. Newton, Jacob Ellegood, Jason P. Lerch, Etienne Sibille, Yuliya S. Nikolova, Mounira Banasr.

Keith Misquitta and colleagues just published his recent work in Neuropharmacology.

 In this research article, we demonstrate that

  • Chronic restraint stress (CRS) decreases anterior cingulate cortex (ACC) volume
  • ACC and amygdala (AMY) volumes negatively correlate with behavioral emotionality
  • CRS decreased the strength and degree of the ACC structural covariance network
  • CRS increased the strength and degree of the AMY structural covariance network
  • PSD95 puncta density correlates with behavioral emotionality and ACC volume.

Full article here