Breno Diniz, M.D., Ph.D.

Dr. Breno Satler Diniz is a Clinician Scientist and Geriatric Psychiatrist at CAMH, Scientist at the Campbell Family Mental Health Research Institute, and Assistant Professor of Psychiatry in the Department of Psychiatry at the University of Toronto.  

Our Research Focus

Dr. Diniz lab goal is to identify central and peripheral biomarkers for understanding the neurobiology of late-life mood and neurocognitive disorders; for improving the identification of older adults at highest risk of cognitive impairment; for tailoring treatment to individuals (precision medicine approach).  

Dr. Diniz lab is focused on 3 main research lines, using a translational medicine approach. First, he is conducting studies to investigate the role of molecular biomarkers of senescence as a mechanism of development cognitive impairment in late-life mood and neurodegenerative disorders (e.g., major depression and Alzheimer’s disease). He is also focused on the analysis of neuronal and astrocyte-derived extracellular vesicles (exosomes and microvesicles) as biomarkers tools for major depression and Alzheimer’s disease (i.e., liquid biopsy for psychiatric disorders). Finally, Dr. Diniz uses complex modelling approaches to integrate multi-modal biomarkers (e.g., genomics, proteomics, molecular and structural neuroimaging) to better understand the biological mechanisms of complex psychiatric disorders.  

Meet the team

Team Publications

Diniz BS, Reynolds Iii CF, Sibille E, Bot M, Penninx BWJH. Major depression and enhanced molecular senescence abnormalities in young and middle-aged adults. Transl Psychiatry. 2019 Aug 21;9(1):198. doi: 10.1038/s41398-019-0541-3. PubMed PMID: 31434875; PubMed Central PMCID: PMC6704136. 

Mendes-Silva AP, Mwangi B, Aizenstein H, Reynolds CF 3rd, Butters MA, Diniz BS. Molecular Senescence Is Associated With White Matter Microstructural Damage in Late-Life Depression. Am J Geriatr Psychiatry. 2019 Dec;27(12):1414-1418. doi: 10.1016/j.jagp.2019.06.006. Epub 2019 Jun 22. PubMed PMID: 31320246; PubMed Central PMCID: PMC6842685. 

Diniz BS, Reynolds CF 3rd, Sibille E, Lin CW, Tseng G, Lotrich F, Aizenstein HJ, Butters MA. Enhanced Molecular Aging in Late-Life Depression: the Senescent-Associated Secretory Phenotype. Am J Geriatr Psychiatry. 2017 Jan;25(1):64-72. doi: 10.1016/j.jagp.2016.08.018. Epub 2016 Aug 31. PubMed PMID:  27856124; PubMed Central PMCID: PMC5164865. 

Diniz BS, Lin CW, Sibille E, Tseng G, Lotrich F, Aizenstein HJ, Reynolds CF, Butters MA. Circulating biosignatures of late-life depression (LLD): Towards a comprehensive, data-driven approach to understanding LLD pathophysiology. J Psychiatr Res. 2016 Nov;82:1-7. doi: 10.1016/j.jpsychires.2016.07.006. Epub 2016 Jul 11. PubMed PMID: 27447786. 

Diniz BS, Sibille E, Ding Y, Tseng G, Aizenstein HJ, Lotrich F, Becker JT, Lopez OL, Lotze MT, Klunk WE, Reynolds CF, Butters MA. Plasma biosignature and brain pathology related to persistent cognitive impairment in late-life depression. Mol Psychiatry. 2015 May;20(5):594-601. doi: 10.1038/mp.2014.76. Epub 2014 Aug 5. PubMed PMID: 25092249; PubMed Central PMCID: PMC4494754. 


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